Hormone Replacement Therapy and Adverse Outcomes in Women With Atrial Fibrillation
نویسندگان
چکیده
Compared with men, women with atrial fibrillation (AF) over age 65 are at greater risk of stroke and thromboembolism. We hypothesized that women with AF taking hormone replacement therapy (HRT) were at greater risk of all-cause death, ischemic stroke, systemic/pulmonary embolism, myocardial infarction (MI), and major bleeding and explored this hypothesis using the large Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) trial data set.
منابع مشابه
Hormone replacement therapy and adverse outcomes in women with atrial fibrillation: an analysis from the atrial fibrillation follow-up investigation of rhythm management trial.
BACKGROUND AND PURPOSE Hormone replacement therapy (HRT) use has been related to thromboembolism, but whether HRT increases adverse outcomes in females with atrial fibrillation is uncertain. METHODS We used the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) trial data set that included 1594 women (39.3% of the population, mean age 71±8), of whom 376 (23.6%) were tak...
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BACKGROUND Observational studies have shown that postmenopausal hormone therapy may increase, decrease, or have no effect on the risk of stroke. To date, no clinical trial has examined this question. To investigate the relation between estrogen plus progestin therapy and risk of stroke among postmenopausal women, we analyzed data collected from the Heart & Estrogen-progestin Replacement Study (...
متن کاملHormone Replacement Therapy and Risk of New-Onset Atrial Fibrillation after Myocardial Infarction - A Nationwide Cohort Study
OBJECTIVES Our aim was to assess the association between use of hormone replacement therapy (HRT) and risk of new-onset atrial fibrillation (AF) after myocardial infarction. DESIGN, SETTING AND PARTICIPANTS We used Danish nationwide registers of hospitalizations and prescriptions to identify all women admitted with myocardial infarction in the period 1997 to 2009 and with no known diagnosis o...
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Hormone replacement therapy (HRT) is associated with risk of vascular disease. The association between atrial fibrillation (AF), vascular events, and different HRTs, including estradiol and conjugated equine estrogens (CEE), has been controversial in previous studies. Thus, we conducted a retrospective cohort study to investigate these associations. Female patients (>45 years old) first diagnos...
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Hormone Replacement Therapy and Cardiovascular Events T he matter regarding hormone replacement therapy and cardiovascular events has been the subject of multiple publications. While observational studies depicted a protection from coronary events in patients receiving hormone replacement therapy, recent randomized trials have failed to show that promising evidence.1 The Heart and Estrogen/Prog...
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تاریخ انتشار 2014